Long-term Side Effects of Taking Gabapentin and What are the most serious side effects ?

The long-term side effects of gabapentin are not known.

Get emergency medical help if you have signs of an allergic reaction to gabapentin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, upper stomach pain, or yellowing of your skin or eyes.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Most people who take gabapentin have mild side effects that go away with no lasting harm, or even no side effects at all. Gabapentin appears to be an exceptionally safe medicine. Indeed, no life-threatening reactions have been linked to it.

It is important to remember that only a tiny number of people who take gabapentin have any serious problems. Tell the doctor right away if you notice anything that worries you, but don’t stop using the gabapentin unless the doctor says so.

Remember that it’s not unusual for gabapentin to make people feel a bit sleepy or uncoordinated. If you’ve just started taking gabapentin or have just had your dosage increased, be careful when doing things that could be dangerous (like driving or operating machinery) until you know how it will affect you. Be particularly cautious if you tend to be sensitive to medications.

On July 10, 2008, an advisory panel was convened by the Food and Drug Administration (FDA) to review data that the FDA had previously collected from drug studies showing an association between many of the antiepileptic drugs (AEDs) and suicidal ideation and behavior, which together are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, 1 out of 1000 people taking the placebo (inactive substance) showed suicidality compared to approximately 3.5 out of 1000 people who took an AED. The FDA advisory panel voted to accept the FDA’s data at its meeting on July 10.

Taking antiepileptic medicines may increase the risk of having suicidal thoughts or actions;

• Do not make any changes to the medication regimen without first talking with the responsible healthcare professional;
• Pay close attention to any day-to-day changes in mood, behavior and actions. These changes can happen very quickly so it is important to be mindful of any sudden differences.

Be aware of common warning signs that might be a signal for risk of suicide. Some of these are:

•  Talking or thinking about wanting to hurt yourself or end your life
•  Withdrawing from friends and family
•  Becoming depressed or having your depression get worse
•  Becoming preoccupied with death and dying
•  Giving away prized possessions